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ACE ABSTRACTS: Angiotensin-Converting Enzyme I/D Polymorphism and Arterial Wall Thickness in a General Population: The Vobarno Study.

Maurizio Castellano, MD; Maria Lorenza Muiesan, MD; Damiano Rizzoni, MD; Marina Beschi, MD; Gianfranco Pasini, MD; Angelo Cinelli, MD; Massimo Salvetti, MD; Enzo Porteri, MD; Giorgio Bettoni, MD; Reinhold Kreutz, MD; Klaus Lindpaintner, MD; Enrico Agabiti Rosei, MD;
[Circulation. 1995;91:2721-2724

BACKGROUND: It has been reported that the D allele of an insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene is associated with conditions of increased cardiovascular risk, including left ventricular hypertrophy.

METHODS AND RESULTS: Considering that a genetically determined overactivity of the renin-angiotensin system may influence cardiac as well as vascular growth, we investigated possible relations between ACE I/D genotype and carotid artery wall thickness (B-mode ultrasound) in 199 subjects, 50 to 64 years old, sampled from the general population of Vobarno, a small town in northern Italy. ACE DD genotype was associated with significantly higher common carotid artery intima-media thickness (P=.003). The occurrence of carotid atherosclerotic plaques was similar in the different genotypes. There was no association of the ACE I/D genotype with blood pressure values (either casual or 24-hour ambulatory monitored).

CONCLUSIONS: ACE DD genotype may be considered a risk factor for the development of common carotid intima-media thickening in our study population.

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